产品货号：
Z32830
中文名称：
CHEK2 (Phospho-T68)抗体
英文名称：
Anti-CHEK2 (Phospho-T68) Antibody (Clone#OTI2H5)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CHEK2 (Phospho-T68) Antibody (Clone#OTI2H5) |
| 指标别名 | CDS1;CHEK2;Chk2;HuCds1;LFS2;PP1425;RAD53 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat,dog |
| 应用范围 | WB,IHC,FCM |
| 基因名称 | CHEK2 |
| 克隆号 | OTI2H5 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG2b |
| 免疫原 | Full length human recombinant protein of human CHEK2 (NP_009125) produced in HEK293T cell. |
| 实际分子量 | 60.7KD |
| 成分 | PBS (pH7.3) containing 1% BSA,50% glycerol and 0.02% sodium azide. |
| 纯化方式 | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | Stable for 12 months from date of receipt.Store at -20℃ as received. |
| 背景资料 | In response to DNA damage and replication blocks,cell cycle progression is halted through the control of critical cell cycle regulators.The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor.It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage.When activated,the encoded protein is known to inhibit CDC25C phosphatase,preventing entry into mitosis,and has been shown to stabilize the tumor suppressor protein p53,leading to cell cycle arrest in G1.In addition,this protein interacts with and phosphorylates BRCA1,allowing BRCA1 to restore survival after DNA damage.Mutations in this gene have been linked with Li-Fraumeni syndrome,a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53.Also,mutations in this gene are thought to confer a predisposition to sarcomas,breast cancer,and brain tumors.This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases.Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq] |
| Uniprot ID | O96017 |
| 基因名全称 | checkpoint kinase 2 |
| 蛋白名全称 | Serine/threonine-protein kinase Chk2 |
| 推荐稀释比 | Western blot (WB) 1:1000～2000 Immunohistochemistry in paraffin section (IHC) 1:150 Flow cytometry (FCM) 1:100 |
相关搜索：CHEK2 (Phospho-T68)抗体，CHEK2 (Phospho-T68)单抗，Anti-CHEK2 (Phospho-T68) Antibody (Clone#OTI2H5)